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Publications

Publications in Peer-Reviewed Journals:
*indicates Bates undergraduate student

Sato, J.D., *Ellis, S.B., *Baker, N., *Brackett, D., *Brown, T., *Godek, S.E., *Tolis, D., and Kleckner, N. (2010) Molecular cloning of neuropeptide hormone NPF cDNA from Helisoma trivolvis. Bulletin of the MDI Biological Laboratory, Vol 49: 29-30.

*Scannell, E., *Dell’Ova, C., Quinlan, E., Murphy, A. D., & Kleckner, N. W. (2008) Pharmacology of ionotropic and metabotropic glutamate receptors on neurons involved in feeding behavior in the pond snail, Helisoma trivolvis, J. Exp. Biol., 221: 824-833.

Kelsey, J. E., Mague, S. D., Pijanowski, R. S., Harris, R. C., Kleckner, N. W., & Matthews, R. T. (2004). NMDA receptor antagonists ameliorate the stepping deficits produced by unilateral medial forebrain bundle injections of 6-OHDA in rats. Psychopharmacology 175: 179-88.

Kleckner, N.W., *Glazewski, J.C., *Chen, C.C. and *Moscrip, T.D. (1999) Subtype-selective antagonism of N-methyl-D-aspartate receptors by felbamate: insights into the mechanism of action.J. Pharmacol. Expt. Ther. 289, 886-894.

Kleckner, N. W. and Pallotta, B. S. (1995). Burst kinetics of single NMDA receptors currents in cell-attached patches from rat brain cortical neurons in culture. J. Physiol. 486.2, 411-426.

Eubanks, J. E., Puranum, R., Kleckner, N. W., Bettler, B., Heinemann, S. F., and McNamara, J. O. (1993). The gene encoding the glutamate recptor subunit GluR5 is located on human chromosome 21q21.1-22.1 in the vicinity of the gene for familial amyotrophic lateral sclerosis.PNAS 90, 178-182.

Kleckner, N. W. and Dingledine, R. (1991). Regulation of NMDA receptors by glycine and magnesium during development. Mol. Brain Res., 11, 151-159, 1991.

Kleckner, N. W. and Dingledine, R. (1989). Selectivity of quinoxalines and kynurenines as antagonists of the glycine site on N-methyl-D-aspartate receptors. Mol. Pharmacol., 36, 430-436.

Mc Bain, C. J., Kleckner, N. W., and Dingledine, R. (1989). Structural requirements for activation of the glycine coagonist site on NMDA receptors expressed in Xenopus oocytes. Mol. Pharmacol., 36, 556-565.

Verdoorn, T. A., Kleckner, N. W., and Dingledine, R. (1989). N-methyl-D-aspartate/glycine and quisqualate/ kainate receptors expressed in Xenopus oocytes. Antagonist pharmacology. Mol. Pharmacol., 35, 360-368.

Kleckner, N. W. and Dingledine, R. (1988). Requirement for glycine in activation of N-methyl-D-aspartate receptors expressed in Xenopus oocytes. Science, 241, 835-837.

Verdoorn, T. A., Kleckner, N. W., and Dingledine, R. (1987). Rat brain N-methyl-D-aspartate receptors expressed in Xenopus oocytes. Science, 238,1114-1116.

Kleckner, N. W., Kizaki, Z., and Thurman, R. G. (1987). Potential intercellular futile cycling of carbohydrates in diabetes. Biochem. J., 246, 417-423.

Gray, T. K., Kleckner, N. W., Malloy, P. J., Sivam, G., Dodd, M. C. and Cohen, M. S. (1987). Biological activity of 19-nor, 10-keto, 25-hydroxy vitamin D3. J. Bone Min. Res., 2, 413-419.

Kleckner, N. W. and Sidell, B. D. (1985). Comparison of maximal activities of enzymes from tissues of thermally acclimated and naturally acclimatized chain pickerel (Esox niger). Physiol. Zool. 58, 18-28.

Recent Abstracts from Meeting Presentations:

*Ho, Q.H. and Kleckner, N.W. (2011) Modulation of the first phase of feeding behavior of Helisoma trivolvis by neuropeptide phenylalanine (NPF) stimulation of buccal A cluster (BAC) neurons­­­. Maine Neuroscience Conference, Bates College, April 23rd.

*Nawreen, N. and Kleckner, N.W. (2011) GluR-5/6/7 and NPF-like immunoreactive (IR) buccal A cluster (BAC) cells in the CNS of the pond snail Helisoma trivolvis. Maine Neuroscience Conference, Bates College, April 23rd.

*Tolis, D. and Kleckner, N.W. (2011) Signal transduction mechanisms of glutamate mediated inhibition of phase 3 motor neurons in the pond snail, Helisoma trivolvis.Maine Neuroscience Conference, Bates College, April 23rd.

Kleckner, N.W. , *Leasure, K.N., *Ho, Q.H., *Nawreen, N., *Tolis, D., *Zhang, A.Y., *Gallo, M.S., *Sousa, G.L., and Wiersma, J. (2011) Neuromodulators and receptors involved in buccal A cluster-mediated state switching of the feeding central pattern generator in the pond snail, Helisoma trivolvis. Society for Neuroscience Online, submitted.

*Contractor, M.M., *Zhang, A.Y., and Kleckner, N.W. (2010) Dye and electrical coupling of buccal A cluster neurons is related to modulation of the feeding central pattern generator in the pond snail, Helisoma trivolvis. Program number 287.19. Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2010. Online. (poster; November, 2010)

Wiersma, J. and Kleckner, N.W. (2010) Characterization of motorneurons of the central pattern generator stimulating feeding behavior in the pond snail Biomphalaria glabrata. Program number 287.17. Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2010. Online. (poster; November, 2010)

*Dharaneeswaran, H. and Kleckner, N.W. (2010) Confirmation and localization of buccalin-like neuropeptides in the central nervous system (CNS) of the pond snails, Biomphalaria glabrata and Helisoma trivolvis. Maine Biomedical Sciences Symposium, MDIBL (Poster presentation; April, 2010). Harita tied for first place in the undergraduate poster competition.

*Qin, J. and Kleckner, N.W. (2010) Differential expression of glutamate recdptot subtypes in Helisoma trivolvis central nervous system. Maine Biomedical Sciences Symposium, MDIBL (Poster presentation; April, 2010).

Wiersma, J. and Kleckner, N.W. (2009) Anatomical and physiological characterization of the central pattern generator stimulating feeding in the pond snail Biomphalaria glabrata. Program number 178.10. Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2009. Online. (poster; November, 2009)

*Gallo, M. and Kleckner, N.W. (2009) Characterization of a novel GluR5/6/7-immunoreactive cell group in the buccal ganglia of the pond snail, Helisoma trivolvis. Program number 178.11. Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2009. Online. (poster; November, 2009) Mimi won first prize in the German Graduate Schools of Neuroscience undergraduate poster competition at the Faculty for Undergraduate Neuroscience session.

Kleckner, N.W. (2009) Modulation of the feeding central pattern generator by glutamate and neuropeptides in the pond snail, Helisoma trivolvis. Molluscan Neuroscience Meeting, San Juan, PR (oral presentation; February, 2009).

Kleckner, N.W. (2009) Modulation of the feeding central pattern generator by glutamate and neuropeptides in the pond snail, Helisoma trivolvis. Maine Biological and Medical Sciences Symposium (oral presentation; April, 2009).

*Gallo, M. and Kleckner, N.W. (2009) Characterization of a novel GluR5/6/7-immunoreactive cell group in the buccal ganglia of the pond snail, Helisoma trivolvis. Molluscan Neuroscience Meeting, San Juan, PR (poster; February, 2009).

*Gallo, M. and Kleckner, N.W. (2009) Characterization of a novel GluR5/6/7-immunoreactive cell group in the buccal ganglia of the pond snail, Helisoma trivolvis. Maine Biological and Medical Sciences Symposium, April 2009, MDIBL, Salibury Cove, ME. Mimi tied for best poster presentation.

*Sousa, G.L and Kleckner, N.W. (2008) Distribution and impact of neuropeptide F (NPF) within the buccal feeding circuitry of the pond snail Helisoma trivolvis. Program No. 574.20. 2008 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2008. Online. Greg won an award for the best undergraduate poster presentation sponsored by the Faculty for Undergraduate Neuroscience and the German Graduate Schools of Neuroscience.

*Klein, P.M. and Kleckner, N.W. (2008) Pharmacological classification of GluR5,6,7 immunoreactive neurons in the buccal ganglia of the pond snail, Helisoma trivolvis. Maine Biomedical Sciences Symposium, MDIBL (April, 2008).

*Ovrutsky, A.R. and Kleckner, N.W. (2008) The effects of drought stress and grazing on the concentration of artemisinin isolated from Artemisia annua samples: Implications in efficacy and toxicity of traditional medicinal plant preparations. Maine Biomedical Sciences Symposium, MDIBL (April, 2008).

*Palmer, M. and Kleckner, N.W. (2008) Characterization of potassium channels implicated in glutamate induced inhibition of buccal neurons in Helisoma trivolvis. Maine Biomedical Sciences Symposium, MDIBL (April, 2008).

*Sousa, G.L. and Kleckner, N.W. (2008) Satiating snails: Investigating the immunohistochemical distribution of neuropeptide Y (NPY)-like molecules in the CNS of the pond snail Helisoma trivolvis and determining NPY’s impact on the buccal feeding circuitry. Maine Biomedical Sciences Symposium, MDIBL (April, 2008).

*Klein, P., *Sousa, G.L., and Kleckner, N.W. (2008) Pharmacological classification of GluR5,6,7 immunoreactive neurons in the guccal ganglia of the pond snail, Helisoma trivolvis. 34th Annual East Coast Nerve Net, Woods Hole Marine Biological Laboratory (April, 2008).

*Marya, N., *Sousa, G., and Kleckner, N.W. (2007) Characterization and Mapping of Glutamate Receptor-Containing Neurons in Helisoma trivolvis Soc. Neurosci. Abstr., Online 140.3 (Nov. 2007) (also presented at the Maine Biomedical Sciences Syposium at MDIBL in May, 2007).

*Scannell, E. and Kleckner N.W. (2007) Pharmacological characterization of excitatory and inhibitory glutamate receptors in buccal neurons B5, B19, and B27 from Helisoma trivolvis, Soc. Neurosci. Abstr., Online 140.2 (Nov. 2007) (also presented at the Maine Biomedical Sciences Syposium at MDIBL in May, 2007).

*Gerhold, K., *Knox, A.S. , Kleckner, N.W. (2005) Cloning and localization of excitatory glutamate receptors from the central nervous system of Helisoma trivolvis. Soc. Neurosci. Abstr., 486.12 (Nov. 2005) (also presented at the Maine Biomedical Sciences Syposium at MDIBL in May, 2005).

*Rafferty, J.R., and Kleckner, N.W. (2005) Glutamate signal transduction pathways causing inhibition in buccal neurons of Helisoma trivolvis, Soc. Neurosci. Abstr., 263.9 (Nov. 2005) (also presented at the Maine Biomedical Sciences Syposium at MDIBL in May, 2005).


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