Martin Kruse – Neurobiology Research
Regulation of nerve cell activity by phosphoinositides
My research is centered around the question how cells of the nervous system regulate their activity. Neurons are permanently exchanging information, and their activity patterns change in milliseconds; however, our understanding of the processes underlying these rapid changes in neuronal activity is still limited. During the last decade, a small class of phospholipids named phosphoinositides has emerged as a key regulator of most aspects of a neuron’s life, and the levels of specific phosphoinositides as well as their localization in a nerve cell profoundly influence neuronal signaling. I am using a combination of genetic, biochemical, electrophysiological, and computational approaches to characterize the multiple roles phosphoinositides fulfill in nerve cells.
Kruse M., Vivas O., Traynor-Kaplan A. and Hille B. (2016) Dynamics of Phosphoinositide-Dependent Signaling in Sympathetic Neurons. J. Neurosci. 36(4): 1386-1400.
Keum D., Kruse M., Kim D.I., Hille B. and Suh B.C. (2016) Phosphoinositide 5- and 3-phosphatase activities of a voltage-sensing phosphatase in living cells show identical voltage dependence. Proc. Natl. Acad. Sci. 113(26): E3686-E3695.
Kruse M., Hammond G.R. and Hille B. (2012) Regulation of voltage-gated potassium channels by PI(4,5)P2. J. Gen. Physiol. 140(2): 189-205.
Selected Mentored Theses:
Kurtbay, Güven 2009. Impaired endocytosis of the ion channel TRPM4 is associated with human progressive familial heart block type I.