Bates Welcomes the Gordon Research Seminar and Conference, July 19–25, 2014

Saturday, July 19

SATURDAY

1:00 pm – 5:00 pm Arrival and Check-in

3:30 pm – 3:45 pm Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair

3:45 pm – 4:30 pm Keynote Session

Discussion Leader: TBA

3:45 pm – 4:15 pm Raphael Kopan (Cincinnati Children’s Hospital Medical Center)

4:15 pm – 4:30 pm Discussion

4:30 pm – 6:00 pm Poster Session I

6:00 pm Dinner

7:30 pm – 9:30 pm Basic Biology and Chemistry of Notch Signaling

Discussion Leaders: TBA

7:30 pm – 7:48 pm Erika Sorensen (University of Wisconsin-Madison), “Visualization of GLP-1/Notch Signaling in Stem Cells Within an Organism”

7:48 pm – 7:54 pm Discussion

7:54 pm – 8:12 pm Kazuya Hori (Harvard Medical School), “Regulation of Notch Signal by a Lysosomal Associated Transmembrane Protein”

8:12 pm – 8:18 pm Discussion

8:18 pm – 8:36 pm Rolake Alabi (Weill Medical College of Cornell University), “Understanding the Contributions of ADAM10 and ADAM17 to Notch1 Signaling”

8:36 pm – 8:42 pm Discussion

8:42 pm – 9:00 pm Catherine Deatherage (Vanderbilt University), “Comparison of the Structures of Gamma-Secretase Substrates Notch and C99-APP”

9:00 pm – 9:06 pm Discussion

9:06 pm – 9:24 pm TBA

9:24 pm – 9:30 pm Discussion

Sunday, July 20

SUNDAY

7:30 am – 8:30 am Breakfast

9:00 am – 10:12 am Notch Signaling in Development and Stem Cells

Discussion Leaders: TBA

9:00 am – 9:18 am Tobias Hohenauer (RIKEN Brain Science Institute), “Evi1 (Prdm3) Maintains Neural Stem Cell Self-Renewal Through Chromatin Control Over Notch Target Activation”

9:18 am – 9:24 am Discussion

9:24 am – 9:42 am Kai-Yuan Chen (Cornell University), “A Gradient Modulated NOTCH Intercellular Feedback Controlling Stem Cell/Niche Pattern Inside Intestinal Crypts”

9:42 am – 9:48 am Discussion

9:48 am – 10:06 am Kostandin Pajcini (University of Pennsylvania), “The Notch1 Transcriptional Activation Domain is Required for Development and Reveals a Novel Role for Notch1 Signaling in Fetal Hematopoietic Stem Cells”

10:06 am – 10:12 am Discussion

10:12 am – 11:00 am Panel Discussion: How Notch Signaling Shapes One’s Career, Discussion Leader: Mustafa Turkoz (Cincinnati Children’s Hospital Medical Center)

Panelists:

Stephen Blacklow (Harvard Medical School, USA)

Sarah Bray (University of Cambridge)

Alain Israël (Institut Pasteur)

Raphael Kopan (Cincinnati Children’s Hospital Medical Center)

Warren Pear (University of Pennsylvania)

Christian Siebel (Genentech)

11:00 am – 12:30 pm Poster Session II

Coffee will be served in the poster area from 11:00 am – 11:30 am

12:30 pm Lunch

1:30 pm – 2:42 pm Notch Signaling in Disease

Discussion Leaders: TBA

1:30 pm – 1:48 pm Sarah Peterson (Maine Medical Center Research Institute), “Notch Signaling in Vascular Remodeling Following Injury”

1:48 pm – 1:54 pm Discussion

1:54 pm – 2:12 pm Surajit Sinha (Memorial Sloan Kettering Cancer Center), “An In Vivo Gain of Function Genetic Screen for Lung Metastasis Identifies NUMB as an Enforcer of Tumor Dormancy”

2:12 pm – 2:18 pm Discussion

2:18 pm – 2:36 pm John Jacob (Oxford University Hospitals NHS Trust), “Cryptic Notch Signaling Mediates Teratogenic Effects of Valproate in a Zebrafish Chemical-Genetics Model of Fetal Valproate Syndrome”

2:36 pm – 2:42 pm Discussion

2:42 pm – 3:00 pm Evaluation Period

Fill in GRS Evaluation Forms

3:00 pm Seminar Concludes


2:00 pm – 9:00 pm Arrival and Check-in for Conference (Office Closed 6:00 pm – 7:00 pm)

6:00 pm Dinner

7:30 pm – 7:40 pm Welcome / Introductory Comments by GRC Site Staff

7:40 pm – 9:30 pm Keynote Session, Discussion Leader: Alain Israel (Institut Pasteur, France)

7:40 pm – 8:10 pm Hans Clevers (Hubrecht Institute, Utrecht, Netherlands), “Wnt, Notch and Intestinal Stem Cells”

8:10 pm – 8:25 pm Discussion

8:25 pm – 8:55 pm Constance Cepko (Harvard), “Development of the Retina”

8:55 pm – 9:10 pm Discussion

9:10 pm – 9:30 pm General Discussion

Monday, July 21

MONDAY

7:30 am – 8:30 am Breakfast

8:30 am Group Photo

9:00 am – 12:30 pm Mechanistic Aspects of Notch Regulation, Discussion Leader: Alain Israel (Institut Pasteur, France)

9:00 am – 9:20 am François Schweisguth (Institut Pasteur, Paris, France), “Real-Time Single-Cell Analysis of Notch in Drosophila”

9:20 am – 9:30 am Discussion

9:30 am – 9:50 am Thomas Klein (Institut für Genetik, Düsseldorf, Germany), “Lgd Mediated Trafficking of Notch”

9:50 am – 10:00 am Discussion

10:00 am Coffee Break

10:30 am – 10:40 am TBA

10:40 am – 10:45 am Discussion

10:45 am – 10:55 am TBA

10:55 am – 11:00 am Discussion

11:00 am – 11:20 am James Posakony (UCSD), “Notch Control of Neural Precursor-Specific Gene Expression”

11:20 am – 11:30 am Discussion

11:30 am – 11:50 am Gabrielle Boulianne (Univ of Toronto, Canada), “Deciphering the Role of Neuralized in Notch Signaling and Beyond”

11:50 am – 12:00 pm Discussion

12:00 pm – 12:20 pm Raphael Kopan (Cincinatti Children’s Hospital), “Non Canonical Notch Signaling in Skin Homeostasis: Facts and Fiction”

12:20 pm – 12:30 pm Discussion

12:30 pm Lunch

1:30 pm – 4:00 pm Free Time

4:00 pm – 6:00 pm Poster Session

6:00 pm Dinner

7:30 pm – 9:30 pm Stem Cells and Development: The Hematopoietic System, Discussion Leader: Lisa Minter (University of Massachusetts, Amherst)

7:30 pm – 7:50 pm Anna Bigas (IMIM, Barcelona, Spain), “Notch Programming of the Hematopoietic Stem Cell Fate”

7:50 pm – 8:00 pm Discussion

8:00 pm – 8:20 pm Irwin Bernstein (Fred Hutchinson, Seattle), “High Notch Signal Strength Renders the Epigenetic Landscape of Hematopoietic Precursors Permissive for T Cell Differentiation”

8:20 pm – 8:30 pm Discussion

8:30 pm – 8:50 pm Utpal Banerjee (UCLA)

“Drosophila Hematopoietic Stem Cells”

8:50 pm – 9:00 pm Discussion

9:00 pm – 9:20 pm Ryoichiro Kageyama (Institute for Virus Research, Kyoto, Japan), “The Significance of Oscillatory Expression of Notch Effectors in Neural Development”

9:20 pm – 9:30 pm Discussion

Tuesday, July 22

TUESDAY

7:30 am – 8:30 am Breakfast

9:00 am – 12:30 pm Notch Signaling in Tissue Development, Discussion Leader: Irwin Bernstein (Fred Hutchinson, Seattle)

9:00 am – 9:10 am TBA

9:10 am – 9:15 am Discussion

9:15 am – 9:25 am TBA

9:25 am – 9:30 am Discussion

9:30 am – 9:50 am Carl Blobel (Hospital for Special Surgery, New York), “The Role of the ADAM10/Notch Pathway in Postnatal Angiogenesis and Pathological Neovascularization”

9:50 am – 10:00 am Discussion

10:00 am Coffee Break

10:30 am – 10:50 am Luisa Iruela-Arispe (UCLA), “Contribution of Notch1 to Vascular Homeostasis”

10:50 am – 11:00 am Discussion

11:00 am – 11:20 am Carmen Birchmeier (Max Delbrück Center, Berlin, Germany), “Notch Signaling in Muscle Development and Regeneration”

11:20 am – 11:30 am Discussion

11:30 am – 11:50 am Stacey Rentschler (Cardiovascular Institute, Univ of Pennsylvania), “Programming and Reprogramming the Cardiac Conduction System”

11:50 am – 12:00 pm Discussion

12:00 pm – 12:20 pm Jose Luis de la Pompa (CNIC, Madrid, Spain), “Insights into Notch Signaling in Cardiac Development and Disease”

12:20 pm – 12:30 pm Discussion

12:30 pm Lunch

1:30 pm – 4:00 pm Free Time

4:00 pm – 6:00 pm Poster Session

6:00 pm Dinner

7:30 pm – 9:30 pm Immunology, Discussion Leader: Warren Pear (University of Pennsylvania)

7:30 pm – 7:50 pm Ivan Maillard (Univ Michigan, Ann Arbor), “Notch Signaling in Alloimmunity and Autoimmunity”

7:50 pm – 8:00 pm Discussion

8:00 pm – 8:20 pm Iannis Aifantis (NYU School of Medicine, New York), “Visualization of Notch Receptor Expression and Activation in the Immune System”

8:20 pm – 8:30 pm Discussion

8:30 pm – 8:50 pm Juan-Carlos Zuniga-Pflücker (Univ of Toronto, Canada), “T Cell Developmental Outcomes and Insights by Temporally Regulating Notch Responsiveness In Vivo”

8:50 pm – 9:00 pm Discussion

9:00 pm – 9:10 pm TBA

9:10 pm – 9:15 pm Discussion

9:15 pm – 9:25 pm TBA

9:25 pm – 9:30 pm Discussion

Wednesday, July 23

WEDNESDAY

7:30 am – 8:30 am Breakfast

9:00 am – 12:30 pm Cancer and Therapeutics, Discussion Leader: Jon Aster (Harvard)

9:00 am – 9:20 am Jon Aster (Harvard), “Notch Regulation of Gene Expression in Cancer”

9:20 am – 9:30 am Discussion

9:30 am – 9:50 am Andrew Weng (Terry Fox Lab, Vancouver, Canada), “Regulation of Leukemia Stem Cell Activity by Notch Signaling”

9:50 am – 10:00 am Discussion

10:00 am Coffee Break

10:30 am – 10:50 am Paolo Dotto (Univ of Lausanne, Switzerland), “Notch and CSL in Cancer Fields”

10:50 am – 11:00 am Discussion

11:00 am – 11:20 am Adolfo Ferrando (Columbia Univ, New York), “Targeting Oncogenic NOTCH1 Signaling Networks in Human Leukemia”

11:20 am – 11:30 am Discussion

11:30 am – 11:50 am Chris Siebel (Genentech), “Therapeutic Antibodies Targeting Individual Notch Ligands and Receptors”

11:50 am – 12:00 pm Discussion

12:00 pm – 12:20 pm Sean Egan (Hospital for Sick Children, Toronto, Canada), “Genetic Analysis of Notch Signaling in Mammary Gland Development and Breast Cancer”

12:20 pm – 12:30 pm Discussion

12:30 pm Lunch

1:30 pm – 4:00 pm Free Time

4:00 pm – 6:00 pm Poster Session

6:00 pm Dinner

7:00 pm – 7:30 pm Business Meeting: Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair

7:30 pm – 9:30 pm Late-Breaking Topics, Discussion Leader: Raphael Kopan (Cincinatti Children’s Hospital)

7:30 pm – 7:40 pm TBA

7:40 pm – 7:45 pm Discussion

7:45 pm – 7:55 pm TBA

7:55 pm – 8:00 pm Discussion

8:00 pm – 8:10 pm TBA

8:10 pm – 8:15 pm Discussion

8:15 pm – 8:25 pm TBA

8:25 pm – 8:30 pm Discussion

8:30 pm – 8:40 pm TBA

8:40 pm – 8:45 pm Discussion

8:45 pm – 8:55 pm TBA

8:55 pm – 9:00 pm Discussion

9:00 pm – 9:10 pm TBA

9:10 pm – 9:15 pm Discussion

9:15 pm – 9:25 pm TBA

9:25 pm – 9:30 pm Discussion

Thursday, July 24

THURSDAY

7:30 am – 8:30 am Breakfast

9:00 am – 10:30 am Cancer and Therapeutics (continued), Discussion Leader: Jon Aster (Harvard)

9:00 am – 9:20 am Anthony Capobianco (University of Miami)

9:20 am – 9:30 am Discussion

9:30 am – 9:50 am Gavin Thurston (Regeneron), “Blocking Dll4-Notch Signaling to Modulate Tumor Angiogenesis”

9:50 am – 10:00 am Discussion

10:00 am Coffee Break

10:30 am – 12:30 pm Structure and Transcription, Discussion Leader: Stephen Blacklow (Harvard Medical School)

10:30 am – 10:50 am Rhett Kovall (Univ of Cincinnati), “Structure and Function of Notch Transcription Complexes”

10:50 am – 11:00 am Discussion

11:00 am – 11:20 am Sarah Bray (Univ of Cambridge, UK), “Decoding the Notch Response”

11:20 am – 11:30 am Discussion

11:30 am – 11:50 am Doug Barrick (Johns Hopkins, Baltimore), “Structural and Functional Properties of the Disordered RAM Region of the Notch Receptor”

11:50 am – 12:00 pm Discussion

12:00 pm – 12:20 pm Susan Lea (Univ of Oxford, UK), “Structural Insights into Binding Partners of Notch Ligands”

12:20 pm – 12:30 pm Discussion

12:30 pm Lunch

1:30 pm – 4:00 pm Free Time

4:00 pm – 6:00 pm Poster Session

6:00 pm Dinner

7:30 pm – 9:00 pm Notch Regulation by Glycosylation, Discussion Leader: Stephen Blacklow (Harvard Medical School)

7:30 pm – 7:50 pm Kenji Matsuno (Osaka University, Japan), “Monomeric O-Fucose and O-Glucose Modifications Have a Redundant Role in the Folding of Notch”

7:50 pm – 8:00 pm Discussion

8:00 pm – 8:20 pm Robert Haltiwanger (Stony Brook Univ, NY), “Regulating Notch by Glycosylation”

8:20 pm – 8:30 pm Discussion

8:30 pm – 8:50 pm Pamela Stanley (Einstein, New York), “O-Glycans that Regulate Notch Signaling”

8:50 pm – 9:00 pm Discussion

9:00 pm – 9:20 pm TBA

9:20 pm – 9:30 pm Discussion

Friday, July 25

FRIDAY

7:30 am – 8:30 am Breakfast

9:00 am Departure