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Publications

Publications (* denotes a Bates College Undergraduate Student)

1. Sommer, R.J., Hume, A.J.*, Ciak, J.M.*, VanNostrand, J.J. Jr.*, Friggens, M. and Walker, M.K. (2005). Early developmental 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure decreases chick embryo heart chronotropic response to isoproterenol but not to agents affecting signals downstream of the beta-adrenergic receptor. Toxicol. Sci. 83, 363-371.

2. Sommer, R.J. (2004). A Successful AREA Grant Proposal in the Biological Sciences. Council on Undergraduate Research Quarterly24(3), 125-128.

3. Lewis, B.C., Hudgins, S., Lewis, A., Schorr, K., Sommer, R.J., Peterson, R.E., Flaws, J.A., and Furth, P.A. (2001). In utero and lactational treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin impairs mammary gland differentiation but does not block the response to exogenous estrogen in the post pubertal female rat. Toxicol. Sci. 62, 46-53.

4. Dienhart, M.K., Sommer, R.J., Silbergeld, E., Peterson, R.E., and Hirshfield, A.N. (2000). Gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin induces developmental defects in the rat vagina. Toxicol. Sci56(1), 141-149.

5. Sommer, R.J., Sojka, K.M., Pollenz, R.S., Cooke, P.S., and Peterson, R.E. (1999). Ah receptor and ARNT protein and mRNA concentrations in rat prostate: Effects of age and 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol. Appl. Pharmacol. 155, 177-189.

6. Flaws, J.A., Sommer, R.J., Silbergeld, E., Peterson, R.E.,and Hirshfield, A.N. (1997). In uteroand lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces genital dysmorphogenesis in the female rat. Toxicol. Appl. Pharmacol. 147, 351-362.

7. Sommer, R.J., and Peterson, R.E. (1997). In utero and lactational exposure of the mouse to2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): Effects on male reproductive tract development.Dioxin ‘97, Organohalogen Compounds 34, 360-363.

8. Sommer, R.J., Ippolito, D.L., and Peterson, R.E. (1996). In utero and lactational exposure of the male holtzman rat to 2,3,7,8-tetrachlorodibenzo-p-dioxin: Decreased epididymal and ejaculated sperm numbers without alterations in sperm transit rate. Toxicol. Appl. Pharmacol. 140, 146-153.

9. Roman, B.L., Sommer, R.J., Shinomiya, K., and Peterson, R.E. (1995). In utero and lactational exposure of the male rat to 2,3,7,8-tetrachlorodibenzo-p-dioxin: Impaired prostate growth and development without inhibited testicular androgen production. Toxicol. Appl. Pharmacol. 134, 241-250.

10. Bjerke, D.L., Sommer, R.J., Moore, R.W., and Peterson, R.E. (1994). Effects of in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on responsiveness of the male rat reproductive system to testosterone stimulation in adulthood. Toxicol. Appl. Pharmacol. 127, 250-257.

11. Vanden Heuvel, J.P., Davis, J.W., Sommer, R., and Peterson, R.E. (1992). Renal excretion of perfluorooctanoic acid in male rats: Inhibitory effect of testosterone. J. Biochem. Toxicol. 7, 31-36.

Abstracts (* denotes a Bates College Undergraduate Student)

1. Gonsalves, K.M.*, Carmody, M.W., and Sommer, R.J.  (2007).  Beta-naphthoflavone induced inhibition of beta2-adrenergic receptor promoter driven luciferase activity is not mediated via putative dioxin response elements. Toxicological Sciences Supplement, Toxicologist,, Abstrace No. 362, in press.

2. Philbrook, L.L.*, Shulan, J.M.*, and Sommer, R.J.  (2007).  High dose prenatal arsenic exposure decreases coronary artery density and increases cardiac fibrosis in mice.  Toxicological Sciences Supplement, Toxicologist, Abstract No. 369, in press.

3. Davie, E.S.*, and Sommer, R.J.  (2006).  Investigations into dioxin response elements (DREs) upstream of beta-adrenergic receptor genes.  Maine Biological and Medical Sciences Symposium, Mount Desert Island, ME, April 28 – 29, 2006.

4. Ciak, J.M.* and Sommer, R.J.  (2005).  Putative dioxin response elements (DREs) upstream of beta-adrenergic receptor genes.  Biological and Medical Sciences Symposium, Mount Desert Island, ME, April 29 – 30, 2005.

5. Ciak, J.M.* and Sommer, R.J.  (2005).  Putative dioxin response elements (DREs) upstream of the beta-adrenergic receptor genes specifically bind AhR and ARNT.  Toxicological Sciences Supplement, Toxicologist84(S-1), Abstract No. 1831.

6. Ciak, J.M.* and Sommer, R.J.  (2004).  Putative Dioxin Response Elements (DREs) Upstream of Beta-Adrenergic Receptor Genes may be Functional. North East Regional Society of Toxicology Meeting, Oct. 8, 2004, in Portland, ME.

7. Sommer, R.J., Hume, A.J.*, Beck, A.P.*, VanNostrand, J.J. Jr.*, and Walker, M.K., (2003). Aryl hydrocarbon receptor (AhR) and cardiac beta-adrenergic receptor signaling. Maine Biological and Medical Sciences Symposium, Mount Desert Island, ME, April 30 – May 1, 2004.

8. Sommer, R.J., and Walker, M.K. (2004). TCDD Decreases responsiveness of the chick embryo heart to isoproterenol but not to agents effecting downstream events of the beta-adrenergic receptor. Toxicologist78(1-S), Abstract No. 1212.

9. Hume, A.J.*, Walker, M.K., and Sommer, R.J. (2003). cDNA sequence of chick beta-1-adrenergic receptor may effect responses to cardiotoxic xenobiotics. Toxicological Sciences Supplement72(S-1), 33.

10. Reamer, C.J.*, Sommer, R.J., and Walker, M.K. (2001). Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cardiac Na+/K+ ATPase. Toxicological Sciences Supplement 60(1), 862.

11. Sommer, R.J., Allard, J.L.*, and Quinn, R.L.* Imposex frequency in samples of dogwhelk (Nucella lapillus) populations in Maine. 21st Annual Meeting of the Society of Environmental Toxicology and Chemistry, Nashville, TN, November 12-16, 2000.

12. Sommer, R.J., Allard, J.L.*, and Quinn, R.L.* Incidence of imposex in samples of Maine’s dogwhelk (Nucella lapillus) populations. “Endocrine Disruptors in the Marine Environment: Impacts on Marine Wildlife and Human Health”, Atlantic Coast Contaminants Workshop, June 22-25, 2000.

13. Lewis, B.C., Hudgins, S., Lewis, A., Schorr, K., Sommer, R.J., Peterson, R.E., Flaws, J. and Furth, P.A. (2000). In utero and lactational TCDD exposure alters estrogen receptor-alpha expression in the rat mammary gland. Toxicological Sciences Supplement 54 (1), 646.

14. Furth, P.A., Lewis, B., Lewis, A., Sommer, R.J., Peterson, R.E. and Flaws, J. (1999). In utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure alters estrogen induced mammary gland growth in the rat. Toxicological Sciences Supplement 48 (1-S), 1008.

15. Sojka, K.M., Sommer, R.J., Cooke, P.S., Peterson, R.E. and Pollenz, R.S. (1999). Ah receptor and ARNT protein concentrations in rat prostate: Effects of age and 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicological Sciences Supplement 48 (1-S), 688.

16. Sommer, R.J. and Peterson, R.E. (1998). In utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure induces accumulations of mononuclear cells in the interstitial tissue of the rat epididymis. Toxicological Sciences Supplement 42(1-S), 487.

17. Dienhart, M.K., Flaws, J.A., Sommer, R.J., Peterson, R.E., Silbergeld, E.K., and Hirshfield, A.N. (1997). 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces developmental defects in the rat vagina. Society for the Study of Reproduction Supplement, 471.

18. Sommer, R.J. and Peterson, R.E. (1996). In utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure decreases epididymal sperm number without altering sperm transit rate in the male rat excurrent duct system. Fundam. Appl. Toxicol. 30, 1014.

19. DeSanti, A.M., Flaws, J.A., Sommer, B., Silbergeld, E., and Hirshfield, A.N. (1996). 2,3,7,8-tetrachlorodibenzodioxin (TCDD) affects vaginal opening in the rat. Society for the Study of Reproduction Supplement, 508.

20. Sommer, R.J., Roman, B.L., Hirshfield, A.N., and Peterson, R.E. (1995). Developmental toxicity of dioxin in the female rat: External genitalia malformations without alterations in primordial follicle number. Toxicologist 15, 292.

21. Roman, B.L., Sommer, R.J., Shinomiya, K., and Peterson, R.E. (1994). Perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) decreases androgen-dependent organ weights in male rats without inhibiting testicular androgen production. Toxicologist 14, 382.

22. Bjerke, D.L., Sommer, R.J., Moore, R.W., and Peterson, R.E. (1993). Perinatal exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can decrease responsiveness to androgens in adulthood. Toxicologist 13, 104.

Invited Seminars

“Developmental Dioxin Exposure and Cardiac Beta-Adrenergic Receptor Signaling” given at Bowdoin College, Brunswick, ME, on Sept. 23, 2004 and at University of Maine Biochemistry Seminar Series, Orono, ME, on Sept. 27, 2004.

“Developmental Cardiovascular Toxicity of Arsenic” given at Univ. of Southern Maine Center for Toxicology and Environmental Health External Advisory Committee Meeting, Portland, ME, August 2, 2004.

“Teaching and Research at Bates College, a Small Liberal Arts Institution” given as part of a Career Development Workshop to biomedical science graduate students at the University of New Mexico, Albuquerque, NM, on March 3, 2003.


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