Lori Banks – Microbiology
During my sophomore year of college, the Ameri-thrax attacks and other subsequent bioterrorism threats changed the tone and focus of my study of biology and chemistry. I discovered that the key to fighting bioterrorism, antibiotic resistance, and epidemic, infectious diseases, all centered on a molecular understanding of host-pathogen interactions. After years in the research lab, I have come to understand that the interactions of molecules drive lots of other kinds of disease as well. Identifying and characterizing the most important of these interactions gives us the starting point for most drug design, and a chance to create new medicine. The focus of the Banks Lab is to understand the key structural features of selected microbial proteins that can be exploited in the design of new anti-microbial agents.
Adamski, C.J., Cardenas, A.M., Brown, N.G., Horton,L.B., Sankaran, B., Prasad, B.V.V., Gilbert, H.F., and T. Palzkill. 2014. Molecular basis for the catalytic specificity of the CTX-M extended-spectrum beta-lactamases. Biochemistry 54(2):447-457.
Sastri, N.P., Viskovska, M., Hyser, J.M., Tanner, M.R., Horton, L.B., Sankaran, B., Prasad, B.V.V., and M.K. Estes. 2014. Structural plasticity of the coiled-coil domain of rotavirus NSP4. J. Virology 88(23):13602-13612.
Chen, P., Horton, L.B., Mikulski, R.L., Deng, L., Sundriyal, S., Palzkill, T., and Y. Song. 2012. 2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-beta-lactamases. Bioorganic & Medicinal Chemistry Letters 22(19):6229-6232.
Lori Banks, PhD
Assistant Professor of Biology
Lewiston, ME 04240