Nancy Kleckner – Neurobiology

Pharmacology and organization of neural circuits that produce and modulate rhythmic behaviors

The overall goal of my research program is to better understand the pharmacology and organization of neural circuits that produce and modulate rhythmic behavior in organisms. My current research focuses mainly on the neuromodulators and receptors that control the feeding behavior of the pond snails, Helisoma trivolvis and Biomphalaria glabrata.

The pond snail, Biomphalaria

The pond snail, Biomphalaria glabrata

Pond snails offer a model system in which large identifiable neurons can be monitored; their activity represents patterned behavioral outputs that can be modified by neurochemicals. Bates undergraduate students have done research projects to investigate pharmacology and function of this system in the central nervous system of the pond snails Helisoma trivolvis and Biomphalaria glabrata Kleckner Faculty page

Selected Publications

* indicates Bates student

Sato, J.D., *Ellis, S.B., *Baker, N., *Brackett, D., *Brown, T., *Godek, S.E., *Tolis, D., and Kleckner, N. (2010) Molecular cloning of neuropeptide hormone NPF cDNA from Helisoma trivolvis. Bulletin of the MDI Biological Laboratory, Vol 49: 29-30.

*Scannell, E., *Dell’Ova, C., Quinlan, E., Murphy, A. D., & Kleckner, N. W. (2008) Pharmacology of ionotropic and metabotropic glutamate receptors on neurons involved in feeding behavior in the pond snail, Helisoma trivolvis, J. Exp. Biol., 221: 824-833.

Selected Mentored Theses

Nawshaba Nawreen (2011) (Biochemistry) – GluR-5/6/7 and NPF-like Immunoreactive (IR) Buccal A Cluster (BAC) Cells in the CNS of Pond Snail Helisoma trivolvis.

Dorian Tolis (2011) (Neuroscience) – Signal Transduction Mechanisms of Glutamate Mediated Inhibition of Phase 3 Motor Neurons in the Pond Snail, Helisoma trivolvis.

Quan Ho (2011) (Neuroscience) – Modulation of the First Phase of Feeding Behavior of Helisoma trivolvis by Neuropeptide Phenylalanine (NPF) stimulation of Buccal A Cluster (BAC) Neurons