Paula J. Schlax
Stella James Sims Professor of Chemistry and Biochemistry
Chemistry and Biochemistry
Bonney Science Center, Room 311
My laboratory is investigating translational regulation, RNA localization and RNA decay in spirochetes, including the organism that causes Lyme disease. I am particularly interested in the importance of the thermodynamics and kinetics of mRNA folding in in regulating RNA levels and translation.
I am also involved in fostering inclusion and equity in STEM.
I always wanted to be a scientist or an engineer. I attended Clarkson University where I earned a B.S. in Chemical Engineering, but more importantly, a love for scientific research through my time in Dr. Petr Zuman’s laboratory. I began teaching and studying molecular interactions that regulate gene expression at the University of Wisconsin-Madison where I earned my Ph.D. in Chemistry. I learned that I wanted a career that valued both teaching and research as a post-doctoral fellow at Johns Hopkins University.
I joined Bates in 1998. I am fascinated by a fundamental question; How is regulation of gene expression as a response to external stimulus achieved? My laboratory is investigating translational regulation, RNA localization and RNA decay in spirochetes, including the organism that causes Lyme disease. I am particularly interested in the importance of the thermodynamics and kinetics of mRNA folding in in regulating RNA levels and translation.
Between working with interesting and talented students in my laboratory and in chemistry courses, and working with the HHMI core leadership team and my colleagues at Bates to transform Bates and to help students thrive, I enjoy spending time with my family, paddling in my hand built kayak, hiking, and photography.
J. Matsunaga, P.J. Schlax, D. Haake, 2013, “A role for cis-acting RNA sequences in the temperature-dependent expression of the multiadhesive Lig proteins in Leptospira interrogans” J. Bacteriol. 195:22 5092-5101.
- Archambault, J. S. Borchert*, J. Bergeron*, S. Snow*, P.J. Schlax, 2013, “Measurements of mRNA Degradation inBorrelia burgdorferi” J. Bacteriol. 195:21 4879-4887.
- Archambault, J. Linscott*, N. Swerdlow*, K. Boyland*, E. Riley* and P.J. Schlax, 2013, “Translational Efficiency of rpoSmRNA from Borrelia burgdorferi: Effects of the Length and Sequence of the mRNA Leader Region” Biochem Biophys Res Commun. 433(1):73-8.
- I. Koleva, C. A. Austin*, J. M. Kowaleski*, D.S. Neems*, L.Wang*, C.P.H. Vary and P.J. Schlax, 2006, “Interactions of Ribosomal Protein S1 with DsrA and rpoS mRNA” Biochem Biophys Res Commun. 348:662-668.
P.J. Schlax and D. J. Worhunsky* “Translational Repression Mechanisms in Prokaryotes”, 2003, Mol. Microb, 48: 1157-1169.
- J. Worhunsky*, K. Godek*, S. Litsch*, & P.J. Schlax“Interactions of the Non-Coding RNA DsrA and rpoS mRNA with the 30S Ribosomal Subunit”, 2003, J. Biol. Chem., 278:15815-15824.