Levi A. Adams
Visiting Assistant Professor of Biology
Carnegie Science Hall, Room 414
Ph.D. Biomedical Sciences, University of Central Florida
I am a Maine native, and grew up on a rural farm in the western mountains. I originally attended culinary arts school and after years of working in the food service industry, I decided to pursue my original interest – biology. I study how aging changes the brain and how those changes can predispose some people to develop neurological diseases such as Parkinson’s disease or Alzheimer’s disease. I use a wide variety of techniques to explore how some people’s protective genes are turned off during aging, and identified a new type of cell in the brain that only shows up in people at risk for neurological diseases.
*Denotes Undergraduate Authors
Adams L, Song MK, Tanaka Y, Kim YS. Single-nuclei paired multiomic analysis of young, aged, and Parkinson’s disease human midbrain reveals age- and disease-associated glial changes and their contribution to Parkinson’s disease (Current under review). Preprint: doi: https://doi.org/10.1101/2022.01.18.22269350.
Guhathakurta S, Adams L, Jeong I, Sivakumar A*, Cha M*, Bernardo Fiadeiro M*, Hu HN, Kim YS. Precise epigenomic editing with a SunTag-based modular epigenetic toolkit. Epigenetics. 2022 Aug 3:1-7. doi: 10.1080/15592294.2022.2106646.
Song MK, Adams L, Lee JH, Kim YS. NXP031 prevents dopaminergic neuronal loss and oxidative damage in the AAV-WT-α-synuclein mouse model of Parkinson’s disease. PLoS One. 2022 Jul 28;17(7):e0272085. doi: 10.1371/journal.pone.0272085.
Jandy M, Noor A*, Nelson P*, Dennys CN, Karabinas IM*, Pestoni JC*, Singh GD*, Luc L*, Devyldere R, Perdomo N, Mitchell CE, Adams L, Fuse MA, Mendoza FA, Marean-Reardon CL, Mehl RA, Estevez AG, Franco MC. Peroxynitrite nitration of Tyr 56 in Hsp90 induces PC12 cell death through P2X7R-dependent PTEN activation. Redox Biol. 2022 Apr;50:102247. doi: 10.1016/j.redox.2022.102247.
Guhathakurta S, Kim J, Adams L, Basu S, Song MK, Adler E*, Je G, Fiadeiro MB*, Kim YS. Targeted attenuation of elevated histone marks at SNCA alleviates α-synuclein in Parkinson’s disease. EMBO Mol Med. 2021 Feb 5;13(2):e12188. doi: 10.15252/emmm.202012188.
Basu S, Adams L, Guhathakurta S, Kim YS. A novel tool for monitoring endogenous alpha-synuclein transcription by NanoLuciferase tag insertion at the 3’end using CRISPR-Cas9 genome editing technique. Sci Rep. 2017 Apr 4;8:45883. doi: 10.1038/srep45883.
Adams L, Franco MC, Estevez AG. Reactive nitrogen species in cellular signaling. Exp Biol Med (Maywood). 2015 Jun;240(6):711-7. doi: 10.1177/1535370215581314.