{"id":4820,"date":"2022-08-01T09:06:18","date_gmt":"2022-08-01T13:06:18","guid":{"rendered":"https:\/\/www.bates.edu\/faculty\/profile\/levi-a-adams\/"},"modified":"2026-02-04T16:08:35","modified_gmt":"2026-02-04T21:08:35","slug":"levi-a-adams","status":"publish","type":"faculty-profile","link":"https:\/\/www.bates.edu\/faculty\/profile\/levi-a-adams\/","title":{"rendered":"Levi A. Adams"},"content":{"rendered":"<p><strong>Ph.D. Biomedical Sciences, University of Central Florida <\/strong><\/p>\n<p>I am a Maine native, and grew up on a rural farm in the western mountains. I originally attended culinary arts school and after years of working in the food service industry, I decided to pursue my original interest &#8211; biology. I study how aging changes the brain and how those changes can predispose some people to develop neurological diseases such as Parkinson&#8217;s disease or Alzheimer&#8217;s disease. I use a wide variety of techniques to explore how some people&#8217;s protective genes are turned off during aging, and identified a new type of cell in the brain that only shows up in people at risk for neurological diseases.<\/p>\n<h2>Selected Publications<\/h2>\n<p>*Denotes Undergraduate Authors<\/p>\n<p><strong>Adams L, Song MK, Tanaka Y, Kim YS.<\/strong> Single-nuclei paired multiomic analysis of young, aged, and Parkinson\u2019s disease human midbrain reveals age- and disease-associated glial changes and their contribution to Parkinson\u2019s disease (Current under review). Preprint: doi: https:\/\/doi.org\/10.1101\/2022.01.18.22269350.<\/p>\n<p><strong>Guhathakurta S, Adams L, Jeong I, Sivakumar A*, Cha M*, Bernardo Fiadeiro M*, Hu HN, Kim YS.<\/strong> Precise epigenomic editing with a SunTag-based modular epigenetic toolkit. Epigenetics. 2022 Aug 3:1-7. doi: 10.1080\/15592294.2022.2106646.<\/p>\n<p><strong>Song MK, Adams L, Lee JH, Kim YS.<\/strong> NXP031 prevents dopaminergic neuronal loss and oxidative damage in the AAV-WT-\u03b1-synuclein mouse model of Parkinson&#8217;s disease. PLoS One. 2022 Jul 28;17(7):e0272085. doi: 10.1371\/journal.pone.0272085.<\/p>\n<p><strong>Jandy M, Noor A*, Nelson P*, Dennys CN, Karabinas IM*, Pestoni JC*, Singh GD*, Luc L*, Devyldere R, Perdomo N, Mitchell CE, Adams L, Fuse MA, Mendoza FA, Marean-Reardon CL, Mehl RA, Estevez AG, Franco MC.<\/strong> Peroxynitrite nitration of Tyr 56 in Hsp90 induces PC12 cell death through P2X7R-dependent PTEN activation. Redox Biol. 2022 Apr;50:102247. doi: 10.1016\/j.redox.2022.102247.<\/p>\n<p><strong>Guhathakurta S, Kim J, Adams L, Basu S, Song MK, Adler E*, Je G, Fiadeiro MB*, Kim YS.<\/strong> Targeted attenuation of elevated histone marks at SNCA alleviates \u03b1-synuclein in Parkinson&#8217;s disease. EMBO Mol Med. 2021 Feb 5;13(2):e12188. doi: 10.15252\/emmm.202012188.<\/p>\n<p><strong>Basu S, Adams L, Guhathakurta S, Kim YS.<\/strong> A novel tool for monitoring endogenous alpha-synuclein transcription by NanoLuciferase tag insertion at the 3&#8217;end using CRISPR-Cas9 genome editing technique. Sci Rep. 2017 Apr 4;8:45883. doi: 10.1038\/srep45883.<\/p>\n<p><strong>Adams L, Franco MC, Estevez AG.<\/strong> Reactive nitrogen species in cellular signaling. Exp Biol Med (Maywood). 2015 Jun;240(6):711-7. doi: 10.1177\/1535370215581314.<\/p>\n","protected":false},"author":1532,"featured_media":4890,"template":"","class_list":["post-4820","faculty-profile","type-faculty-profile","status-publish","has-post-thumbnail","hentry","expertise-aging","expertise-genetics","expertise-neuroscience","expertise-transcriptomics"],"_links":{"self":[{"href":"https:\/\/www.bates.edu\/faculty\/wp-json\/wp\/v2\/faculty-profile\/4820","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bates.edu\/faculty\/wp-json\/wp\/v2\/faculty-profile"}],"about":[{"href":"https:\/\/www.bates.edu\/faculty\/wp-json\/wp\/v2\/types\/faculty-profile"}],"author":[{"embeddable":true,"href":"https:\/\/www.bates.edu\/faculty\/wp-json\/wp\/v2\/users\/1532"}],"version-history":[{"count":11,"href":"https:\/\/www.bates.edu\/faculty\/wp-json\/wp\/v2\/faculty-profile\/4820\/revisions"}],"predecessor-version":[{"id":4900,"href":"https:\/\/www.bates.edu\/faculty\/wp-json\/wp\/v2\/faculty-profile\/4820\/revisions\/4900"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bates.edu\/faculty\/wp-json\/wp\/v2\/media\/4890"}],"wp:attachment":[{"href":"https:\/\/www.bates.edu\/faculty\/wp-json\/wp\/v2\/media?parent=4820"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}