Martin Kruse

Martin_Kruse_photo

Assistant Professor of Biology & Neuroscience

Education

  • Diploma (equivalent to B.S. & M.S.), Biochemistry & Molecular Biology, University of Hamburg (2004)
  •  Philosophiae Doctor, Chemistry, University of Hamburg (2009)
  •  Postdoctoral Fellowship, Department of Physiology & Biophysics, University of Washington (2010)

Courses Taught

  •  BI/NS 308 Neurobiology / Lab
  •  BIO 242 Cellular & Molecular Biology / Lab
  •  BIO 321 Cellular Biochemistry
  •  BIO 473 Seminar and Research in Cell Biology
  •  NRSC 460 Capstone Seminar on Cellular Neuroscience

Research Interests

Over the last decade phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), a minor membrane phospholipid of the phosphoinositide family, has emerged as a key regulator of nerve cell activity. PI(4,5)P2 interaction with voltage-gated ion channels is essential for a large number of these channels. In addition, PI(4,5)P2 is critically involved in exo- and endocytosis, influencing neurotransmitter release and reuptake. A fundamental problem is how neurons accurately control PI(4,5)P2 levels, and quickly and reversibly adjust them to an altered physiological situation. However, despite the importance of phosphoinositides for the regulation of neuronal activity, little is known about how the metabolism of phosphoinositides is regulated in cells of the nervous system. To address this question, my research focuses on two major
areas:

  • Analysis of individual steps of phosphoinositide metabolism in a model system for hippocampal neurons by a combination of experimental and computational approaches. Development of mathematical models of phosphoinositide-dependent processes such as action potential firing of hippocampal neurons in response to simulated stimulation by neurotransmitters.
  • Analysis of second messenger signaling downstream of PI(4,5)P2 hydrolysis, specifically mediation of intracellular Ca2+-signaling by IP3 receptor-binding protein released with inositol 1,4,5-trisphosphate.

Selected Publications

1. Dai G, Yu H, Kruse M, Traynor-Kaplan A, and Hille B (2016). Osmoregulatory inositol
transporter SMIT1 modulates electrical activity by adjusting PI(4,5)P2 levels. Proc Natl
Acad Sci USA 113: E3290-9.

2.  Keum D*, Kruse M*, Kim DI, Hille B, and Suh BC (2016). Phosphoinositide 5- and 3-                         phosphatase activities of a voltage-sensing phosphatase in living cells show identical voltage
dependence. Proc Natl Acad Sci USA 113: E3686-95. * These authors contributed equally
to this work.

3. Yu H, Benitez SG, Jung SR, Altamirano LE, Kruse M, Seo JB, Koh DS, Munoz EM, and
Hille B (2016). GABAergic signaling in the rat pineal gland. J Pineal Res 61: 69-81.

4. Dickson EJ, Jensen JB, Vivas O, Kruse M, Traynor-Kaplan A, and Hille B (2016). Rapid
formation of ER-PM junctions recruits a lipid phosphatase and regulates phosphoinositide
metabolism. JCB 213: 33-48.

5. Kruse M*, Vivas O*, Traynor-Kaplan A, and Hille B (2016). Dynamics of phosphoinositide-         dependent signaling in sympathetic neurons. J Neurosci 36: 1386-400. * These authors                contributed equally to this work.

6. Hille B, Dickson EJ, Kruse M, Vivas O, Suh BC (2015). Phosphoinositides regulate ion
channels. Biochim Biophys Acta 1851: 844-56.

7. Vivas O*, Kruse M*, Hille B (2014). Nerve growth factor sensitizes adult sympathetic
neurons to the proinflammatory peptide bradykinin. J Neurosci 34: 11959-71. * These authors  contributed equally to this work.

8. Kruse M, Pongs O (2014). TRPM4 channels in the cardiovascular system. Curr Opin
Pharmacol 15: 68-73.

9. Hille B, Dickson E, Kruse M, Falkenburger B (2014). Dynamic metabolic control of an ion
channel. Prog Mol Biol Transl Sci 123: 219-47.

10. Kruse M, Hille B (2013). The phosphoinositide sensitivity of the KV channel family. Channels
7: 530- 6.

11. Schattling B, Steinbach K, Thies E, Kruse M, Menigoz A, Ufer F, Flockerzi V, Brück W,
Pongs O, Vennekens R, Kneussel M, Freichel M, Merkler D, Friese MA (2012). TRPM4
cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis. Nat Med 18: 1805-11.

12. Mandal G, Sharma M, Kruse M, Sander-Juelch C, Munro LA, Wang Y, Vilg JV, Tamás
MJ, Bhattacharjee H, Wiese M, Mukhopadhyay R (2012). Modulation of Leishmania major
aquaglyceroporin activity by a mitogen-activated protein kinase. Mol Microbiol 85: 1204-18.

13. Kruse M, Hammond GR, Hille B (2012). Regulation of voltage-gated potassium channels
by PI(4,5)P2. J Gen Physiol 140: 189-205.

14. Klaiber M*, Dankworth B*, Kruse M*, Hartmann M, Nikolaev VO, Yang RB, Völker
K, Gassner B, Oberwinkler H, Feil R, Freichel M, Groschner K, Skryabin BV, Frantz S,
Birnbaumer L, Pongs O, Kuhn M (2011). A cardiac pathway of cyclic GMP-independent
signaling of guanylyl cyclase A, the receptor for atrial natriuretic peptide. Proc Natl Acad
Sci USA 108: 18500-5. * These authors contributed equally to this work.

15. Sachse G, Kruse M, Pongs O (2011). Genetically modified mice: Useful models to study
cause and effect of cardiac arrhythmias? Heart Rate and Rhythm, 473-84.

16. Klaiber M, Kruse M, Völker K, Schr¨oter J, Feil R, Freichel M, Baba HA, Pongs O, Penninger
JM, and Kuhn M (2010). Novel insights into the mechanisms mediating the local antihypertrophic
effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase
and RGS2. Basic Res Cardiol 105: 583-95.

17. Liu H*, El Zein L*, Kruse M*, Guinamard R, Beckmann A, Bozio A, Kurtbay G,
Mégarbané A, Ohmert I, Blaysat G, Vilain E, Pongs O, and Bouvagnet P (2009). Gain-of-
function mutations in TRPM4 cause autosomal dominant isolated cardiac conduction disease.
Circ Cardiovasc Genet 3: 374-85. * These authors contributed equally to this work.

18. Kruse M*, Schulze-Bahr E*, Corfield V*, Beckmann A, Stallmeyer B, Kurtbay G, Ohmert
I, Schulze-Bahr El, Brink P, and Pongs O (2009). Impaired endocytosis of the ion channel
TRPM4 is associated with human progressive familial heart block type I. JCI 119: 2737-44.
* These authors contributed equally to this work.

19. Wang Q, Melzer IM, Kruse M, Sander-Juelch C, and Wiese M (2005). LmxMPK4, a
mitogen-activated protein (MAP) kinase homologue essential for promastigotes and amastigotes
of Leishmania mexicana. Kinetoplastid Biol Dis 4: 6.

20. Cross FR, Schroeder L, Kruse M, and Chen KC (2005). Quantitative characterization of a
mitotic cyclin threshold regulating exit from mitosis. Mol Biol Cell 16: 2129-38.

 

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