{"id":98096,"date":"2015-12-04T09:56:11","date_gmt":"2015-12-04T14:56:11","guid":{"rendered":"https:\/\/www.bates.edu\/news\/?p=98096"},"modified":"2018-11-09T13:32:46","modified_gmt":"2018-11-09T18:32:46","slug":"bates-in-the-news-dec-4","status":"publish","type":"post","link":"https:\/\/www.bates.edu\/news\/2015\/12\/04\/bates-in-the-news-dec-4\/","title":{"rendered":"Bates in the News: Dec. 4, 2015"},"content":{"rendered":"

Dana Professor of Chemistry Glen Lawson<\/h3>\n

Helping our cells help themselves to fight disease-causing viruses \u2014 Nature Immunology<\/em><\/a><\/h5>\n

Interferons are a basic way that our bodies fight everything from the sniffles to certain cancers.<\/p>\n

Released by cells when threatened, these proteins tell nearby cells to, in a sense, \u201cinterfere\u201d with the work of sickness-causing pathogens, such as viruses, bacteria, parasites, and also certain tumor cells.<\/p>\n

Scientists have long sought to understand the complex mechanisms by which interferons function. By understanding interferons, they can then make them more effective.<\/p>\n

An article in the December issue of Nature Immunology,<\/em><\/u> co-authored by Dana Professor of Chemistry Glen Lawson, suggests that they’ve found a way. The study was directed by Michael Holtzman, and the lead author is Yong Zhang, both of the Washington University School of Medicine.<\/p>\n

What they’ve done is make cells have “hyper-responsiveness to interferon” (a good thing) and also have “markedly improve[d] antiviral function” (a great thing). The work was done on mice cells and some human cells in the lab.<\/p>\n

\"Glen<\/a>

Glen Lawson receives congratulations from President Spencer at the celebration of his appointment as the Charles A. Dana Professor of Chemistry. (Phyllis Graber Jensen\/Bates College.)<\/p><\/div>\n

They achieved this hyper-responsiveness by stimulating the interferon antivirus response at the gene-expression level.<\/p>\n

The scientists discovered that this response depends upon a certain type of protein, known as an \u201cubiquitin ligase,\u201d which does two things: It stimulates interferon-activated gene expression and it participates in the destruction of a key viral protein.<\/p>\n

Lawson is an expert on ubiquitin ligases and researches their role in infections of mammalian cells by picornaviruses, a family of viruses responsible for causing a large number of diseases.<\/p>\n

The paper to which he contributed is “PARP9-DTX3L Ubiquitin Ligase Targets Host Histone H2BJ and Viral 3C Protease to Enhance Interferon Signaling and Control Viral Infection.”<\/p>\n

\n

The late Jack Sandler ’02<\/h3>\n

A tribute to a man who “pushed us forward and softened our falls with equal grace.” \u2014 Inside Lacrosse<\/em> <\/a><\/h5>\n

In his latest column for Inside Lacrosse<\/em>, men’s lacrosse head coach Peter Lasagna honors the memory of late Jack Sandler ’02<\/a>, head coach of men’s lacrosse at Colby.<\/p>\n

Sandler died Nov. 19 while on a recruiting trip, reportedly collapsing during a workout.<\/p>\n

Sandler played for Lasagna and later was one of his assistant coaches. The column begins with a story about Sandler’s reaction to a great disappointment, when Lasagna did not name him the Bates captain in his senior year, 2001-02.<\/p>\n

\"web-sandler-120302-0715\"<\/a>

In this 2012 photograph, Jack Sandler ’02 (left), then head coach of men’s lacrosse at Skidmore College, laughs with his former Bates coach, Peter Lasagna, after Bates faced Skidmore. Sandler, who became head coach of Colby men’s lacrosse in 2014, died on Nov. 19, 2015. (Phyllis Graber Jensen\/Bates College)<\/p><\/div>\n

Sandler’s reaction was to seek out Lasagna to discuss his feelings.<\/p>\n

“I learned a lot about Jack Sandler\u2019s character that day,” writes Lasagna. “He chose dialogue over repression and resentment. Even when talking about serious disappointment around what mattered most to him, he engaged, listened, and learned.”<\/p>\n

As Sandler graduated and moved into coaching, he maintained that ability. “He pushed us forward and softened our falls with equal grace,” Lasagna writes.<\/p>\n

A memorial service for Jack Sandler <\/a>will be held at Colby College, in the Lorimer Chapel, at 10 a.m. Saturday, Dec. 5.<\/p>\n

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Kate Gilmore ’97<\/h3>\n

A “rich experience,” like a “hallucination,” inspires $200K grand prize \u2014 Michigan Live<\/em><\/a><\/h5>\n

Kate Gilmore ’97 won one of two $200,000 juried grand prizes for her installation “Higher Ground” in a competition sponsored by ArtPrize and held annually in Grand Rapids, Mich.<\/p>\n

An installation that’s better seen than described<\/a>, “Higher Ground” took over a single-family dwelling on Rumsey Street where, around the clock, women in long white dresses and red shoes swayed back and forth on swings mounted from the ceiling in front of, and sometimes through, open windows.<\/p>\n

This video was produced by <\/em>Michigan Live:<\/p>\n