{"id":99,"date":"2023-05-23T12:36:29","date_gmt":"2023-05-23T16:36:29","guid":{"rendered":"https:\/\/www.bates.edu\/science-resource-support-services\/?page_id=99"},"modified":"2026-03-30T13:16:21","modified_gmt":"2026-03-30T17:16:21","slug":"mark-lessard-science-resource-technician","status":"publish","type":"page","link":"https:\/\/www.bates.edu\/science-resource-support-services\/mark-lessard-science-resource-technician\/","title":{"rendered":"Mark Lessard (Science Resource Technician)"},"content":{"rendered":"\n
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Mark D. Lessard<\/p>

Pronouns:<\/i>he\/him\/his<\/p>

\n\t\t\t\tmlessard@bates.edu<\/a>\n\t\t\t<\/p>

Science Resource Technician – Microscopy and Greenhouse<\/span>
Science Resource Support Services<\/span>
207-786-8216<\/a>
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About<\/strong><\/p>\n\n\n\n

I have spent the largest part of my 24 year career working in the field of microscopy. The first 16 years at the Jackson Laboratory working in and managing their Imaging Sciences core, followed by a 6 year stint at Yale. There I worked in the cell biology department managing a super resolution microscopy development lab. I joined Bates in 2021, and now oversee all the microscopy equipment on campus, manage the research greenhouse in Carnegie, and serve as backup to the vivarium coordinator.<\/p>\n\n\n\n

Expertise<\/strong><\/p>\n\n\n\n

Microscopy (super resolution, fluorescence, widefield, SEM), Sample preparation, Image analysis, CAD design<\/p>\n\n\n\n

Selected Publications<\/strong><\/p>\n\n\n\n

An integrated platform for high-throughput nanoscopy AES Barentine, Y Lin, EM Courvan, P Kidd, M Liu, L Balduf, T Phan, … Nature Biotechnology, 1-8 2023 <\/p>\n\n\n\n

U2AF1 Splicing Factor Mutations Affect RNA Subcellular Compartmentalization in Myeloid Malignancies G Biancon, E Busarello, MD Lessard, E Courvan, DA Escayola, … Blood 140 (Supplement 1), 1271-1272 2022 <\/p>\n\n\n\n

Precision analysis of mutant U2AF1 activity reveals deployment of stress granules in myeloid malignancies G Biancon, P Joshi, JT Zimmer, T Hunck, Y Gao, MD Lessard, … Molecular Cell 82 (6), 1107-1122. e7 2022 <\/p>\n\n\n\n

U2AF1 Mutations Enhance Stress Granule Response in Myeloid Malignancies G Biancon, P Joshi, JT Zimmer, T Hunck, Y Gao, MD Lessard, … Blood 138 (Supplement 1), 321-321 2021 <\/p>\n\n\n\n

Three-dimensional adaptive optical nanoscopy for thick specimen imaging at sub-50-nm resolution X Hao, ES Allgeyer, DR Lee, J Antonello, K Watters, JA Gerdes, … Nature methods 18 (6), 688-693 2021 <\/p>\n\n\n\n

Multi-omics profiling of U2AF1 mutants dissects pathogenic mechanisms affecting RNA granules in myeloid malignancies G Biancon, P Joshi, JT Zimmer, T Hunck, Y Gao, MD Lessard, … bioRxiv, 2021.04. 22.441020 2021 <\/p>\n\n\n\n

Implementation of a 4Pi-SMS super-resolution microscope J Wang, ES Allgeyer, G Sirinakis, Y Zhang, K Hu, MD Lessard, Y Li, … Nature Protocols 16 (2), 677-727 2021 <\/p>\n\n\n\n

Nanoscale subcellular architecture revealed by multicolor three-dimensional salvaged fluorescence imaging Y Zhang, LK Schroeder, MD Lessard, P Kidd, J Chung, Y Song, … Nature methods 17 (2), 225-231 2020<\/p>\n\n\n\n

Links<\/strong><\/p>\n\n\n\n

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Mark’s ORCID account<\/a><\/p>\n\n\n\n

Mark’s CV<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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Departments and Programs<\/h3>\n\n\n\n