Martin Kruse

Assistant Professor of Biology and Neuroscience

Associations

Biology

Carnegie Science Hall, Room 310

Neuroscience

Carnegie Science Hall, Room 310

207-755-5932mkruse@bates.edu

About

Ph.D. in Chemistry, University of Hamburg, Germany

Research Interests

My research is centered around the question how cells of the nervous system regulate their activity. Neurons are permanently exchanging information, and their activity patterns change in milliseconds; however, our understanding of the processes underlying these rapid changes in neuronal activity is still limited. During the last decade, a small class of phospholipids named phosphoinositides has emerged as a key regulator of most aspects of a neuron’s life, and the levels of specific phosphoinositides as well as their localization in a nerve cell profoundly influence neuronal signaling. I am using a combination of genetic, biochemical, electrophysiological, and computational approaches to characterize the multiple roles phosphoinositides fulfill in nerve cells.

Student Research Opportunities

Are you interested in being involved in research projects that address questions of signaling networks in nerve cells? Would you like to learn more about molecular biology or confocal microscopy? Does calcium imaging or computational biology sound fascinating to you? All of these topics are part of daily research activities in my laboratory and there are many potential research projects for students available. Please contact me if you would like to learn more about student research opportunities in my group and I would be excited to discuss this with you!

Selected Publications

  • Kruse M., Kohout S.C., Hille B. (2019) Reinterpretation of the substrate specificity of the voltage-sensing phosphatase during dimerization. J. Gen. Physiol. 151(2): 258-263
  • Traynor-Kaplan, A., Kruse M, Dickson E.J., Dai G., Vivas O., Yu H., Whittington D., Hille B. (2017) Fatty-acyl chain profiles of cellular phosphoinositides. Biochim. Biophys. Acta. 1862(5): 513-522
  • Vivas O., Kruse M., Hille B. (2014) Nerve growth factor sensitizes adult sympathetic neurons to the proinflammatory peptide bradykinin. J. Neurosci. 34(36): 11959-71